Table 3.
Predictors of Survival With Native LLiver at 2 Years (Univariate and Multivariate Analysis).
| Factors | SNL 2 years (n = 27) | No survival at 2 years (n = 34) | Effect size (95% CI) | P value | Logistic Regression Analysis |
|---|---|---|---|---|---|
| Age of presentation (days) | 71.5 ± 22.1 | 82.9 ± 31.7 | −11.4 (−25.7 to 3.1) | 0.120 | |
| Age at KPE (days) | 81.9 ± 24.7 | 92.7 ± 32.5 | −10.8 (−25.8 to 4.4) | 0.160 | |
| Bilirubin at 3 months (mg/dl) | 3.2 ± 3.1 | 12.5 ± 5.2 | −9.3 (-11.5 to -7.1) | < 0.0005 | NS |
| Albumin at 3 months (G/dl) | 2.9 ± 0.8 | 2.3 ± 0.5 | 0.6 (0.2–1) | 0.005 | NS |
| Transient elastography (kPa) | 40.7 ± 29.7 | 39.6 ± 27 | 1.1 (−14.1 to 16.4) | 0.967 | |
| Presence of BASM | 2 (7.4%) | 6 (17.6%) | 0.7 (0.44–1.1)a | 0.283 | |
| Presence of DPM | 3 (11.1%) | 5 (14.7%) | 0.88 (0.49–1.6)a | 1 | |
| Presence of advanced fibrosis | 17 (62.9%) | 24 (70.6%) | 0.85 (0.5–1.4)a | 0.590 | |
| Use ofsteroidsafterKPE | 14 (51.8%) | 9 (26.5%) | 1.73 (0.99–3)a | 0.037 | NS |
| Cholangitis | 15 (55.6%) | 26 (76.5%) | 0.63 (0.35–1.132)a | 0.105 | |
| Successful KPE | 23 (85.2%) | 1 (2.9%) | 21.4 (3.1–146)a | <0.0005 | Adjusted OR 115.5 (95% CI 11.9–1119), P < 0.0005 |
BASM, biliary atresia splenic malformation; CI, confidence interval; DPM, ductal plate malformation; kPa, kilo-Pascals; KPE, Kasai portoenterostomy; NS, not significant; OR, odds ratio.
a
Effect size described as odds ratio.