Table 2.
Cost Parameters for Assessing Cost-effectiveness of Sorafenib Versus BSC.
| Parameter | Type of cost | Monthly cost INR (USD) | 95% confidence interval |
Distribution | Source | |
|---|---|---|---|---|---|---|
| Lower INR (USD) | Upper INR (USD) | |||||
| Sorafenib | ||||||
| Drug | OOP | 4730 (73.3) | 4396 (68.1) | 5064 (78.4) | gamma | Review of private chemist sources |
| Laboratory investigation | HS | 2757 (42.7) | 2416 (37.4) | 3098 (48.0) | gamma | 12, 18 |
| Management of adverse effects | ||||||
| Hand foot syndrome | OOP | 36 (0.6) | 30 (0.5) | 41 (0.6) | gamma | 21, 22 |
| Diarrhoea | OOP | 12 (0.2) | 9 (0.1) | 16 (0.2) | gamma | 21, 22, 23 |
| Hyper-tension | OOP | 50 (0.8) | 24 (0.4) | 77 (1.2) | gamma | 22, 23 |
| Rash | OOP | 231 (3.6) | 113 (1.8) | 349 (5.4) | gamma | Review of private chemist sources |
| Nausea | OOP | 1.07 (0.02) | 0.85 (0.01) | 1.3 (0.02) | gamma | 22, 23 |
| Pain | OOP | 28 (0.4) | 23 (0.5) | 33 (0.5) | gamma | 21, 22 |
| BSC | ||||||
| Laboratory investigation | HS | 884 (13.7) | 857 (13.3) | 910 (14.1) | gamma | 18 |
| CECTa | HS | 2025 (31.4) | 1567 (24.3) | 2483 (38.5) | gamma | 18 |
| CECTb | HS | 1350 (20.9) | 1044 (16.2) | 1656 (25.6) | gamma | 18 |
| Management of complications | ||||||
| Pain | OOP | 10,228 (158.4) | 7774 (120.4) | 12,682 (196.4) | gamma | Review of private chemist sources |
| Nutritional protein | OOP | 1310 (20.2) | 1094 (16.9) | 1526 (23.6) | gamma | Review of private chemist sources |
| Ascites | OOP | 6 (0.1) | 5 (0.1) | 7 (0.1) | gamma | 22 |
| UGIE varices | OOP | 11 (0.2) | 3 (0.1) | 18 (0.3) | gamma | 22, 23 |
| Nausea | OOP | 1.07 (0.02) | 0.85 (0.01) | 1.3 (0.02) | gamma | 22, 23 |
| Jaundice | OOP | 544 (8.4) | 387 (5.9) | 702 (10.8) | gamma | 22, 23 |
| Per outpatient consultation | HS | 259 (4.0) | 109 (1.7) | 408 (6.3) | gamma | 33 |
| Per patient bed days General Ward | OOP | 2219 (34.4) | 870 (13.5) | 3569 (55.3) | gamma | 12, 33 |
| Per patient bed days ICU | OOP | 12,801 (198.3) | 12,597 (195.1) | 13,005 (201.4) | gamma | 12, 24 |
1 USD = INR 64.56.
INR: Indian national rupee, USD: US dollar, OOP: out of pocket, HS: health system, BSC: best supporting care, ICU: intensive care unit, CECT: contrast enhanced computed tomography, UGIE: upper gastrointestinal endoscopy.
a
10% of patients requiring CECT.
b
20% of patients requiring CECT.