Table II.
Current trials of TVEC in cutaneous malignancies
| Treatment trial design | Cancer types | Indication | Clinical Trials.gov Registry no. |
|---|---|---|---|
| TVEC monotherapy | Phase II MCC, SCC, and BCC |
Locally advanced | NCT03458117 |
| TVEC ± radiotherapy | Phase II MCC and melanoma |
Locally advanced | NCT02819843 |
| TVEC + nivolumab | Phase II MCC, SCC, and BCC |
Locally advanced or widely metastatic | NCT02978625 |
| TVEC + pembrolizumab | Phase Ib/III melanoma |
Locally advanced or widely metastatic | NCT02263508 |
BCC, Basal cell carcinoma; SCC, squamous cell carcinoma.