Table I.

Summary of reported cases of comedonal lupus in the English-language literature

Case	Age/sex	Time to diagnosis (y)	Sites of acneiform lesions	DIF	Concurrent SLE	Antinuclear antibody	Treatments	Follow-up
Haroon and Fleming2	28/F	6	Upper arms, shoulders, back	Positive	No	Negative	—	—
Motel et al3	29/F	7	Face, upper trunk	Negative	Yes	Positive (1:2560) homogenous	Tetracycline, erythromycin	No improvement
Motel et al3	24/F	—	Face, neck	IgG in nucleoli of focal keratinocytes	Yes	Positive (1:5120) nucleolar	Erythromycin 250 mg QID	No improvement
Chang et al4	32/M	3	Right nasolabial fold	IgG + C3 along BMZ	No	Negative	—	—
Stavrakoglou et al5	38/M	7	Face, chest, back	Negative	No	Negative	1.Erythromycin, 500 mg BID + adapalene daily → 2. Hydroxychloroquine, 200 mg BID, sunscreen	1.No improvement 2.Marked improvement in 4 mo, clear in 1 y
Hemmati et al6	33/F	1.5	Scalp	—	No	—	1.Hydroxychloroquine, 200 mg BID + betamethasone diproprionate 0.05% lotion + ILTAC 5 mg/cc→ 2.Tretinoin 0.025% cream + hydroxychloroquine for 2.5 mo → 3.Hydroxychloroquine, 200 mg BID, ILTAC 10 mg/cc, clobetasol, manual extraction, excision	1.No improvement 2.No improvement 3.Lesions flattened and stabilized
Farias et al7	35/F	2	Face, ear	—	No	—	1.Tetracycline 500 mg BID × 3 weeks then 250 mg BID × 30 days→ 2.Hydroxychloroquine, 400 mg daily	1.Some improvement in pruritus and number of comedones 2.Improvement in 45 d, marked improvement in 6 mo
Vieira et al8	32/F	2	Face	IgM along BMZ and upper dermal vessels	No	Negative	Prednisone 40 mg × 1 mo then tapered over 4 mo + chloroquine, 250 mg daily	Significant improvement at 3 mo, no new lesions at 4 ys
Current case	57/F	1	Face, ears, neck	—	No	Positive (1:80) speckled	Topical clindamycin, tretinoin, benzoyl peroxide, oral doxycycline	No improvement

BID, Twice daily; BMZ, basement membrane zone; DIF, direct immunofluorescence; ILTAC, intralesional triamcinolone; SLE, systemic lupus erythematosus; QID, 4 times daily.