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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: J Immunol. 2013 Jun 21;191(3):1001–1005. doi: 10.4049/jimmunol.1203520

Figure 2: Heterosubtypic infection is associated with a decrease in HA-specific antibody.

Figure 2:

HA- (Panels A and B) and NP-specific (Panel C) ELISA assays were performed on serum obtained from B10.S mice following primary and secondary influenza infection (open and closed circles, respectively). Serum from mice infected with X-31 8 to 9 weeks prior and from naïve mice served as controls (open and closed triangles, respectively). Each point represents the average of sera from 4 to 9 individual mice (experimental groups) or 2 to 5 individual mice (control groups). Error bars depict the standard error of the mean. Panel D demonstrates the results of a microneutralization assay performed on sera obtained from individual B10.S mice at 22 days post infection. Horizontal lines show the geometric mean of each group. A one-way ANOVA with Bonferroni’s Multiple Comparison Test was used to compare groups, with asterisks denoting statistical significance.