Table 2.
Significantly altered metabolites (p < 0.05) in the cell line UM-SCC-74A between cells irradiated with 2 Gy [assessed 4 h (rapid) or 24 h (intermediate) after irradiation] vs. non-irradiated cells (control) from the analysis in negative ionization mode are presented as fold changes (95% confidence intervals).
| Metabolite | Rapid vs. control | Intermediate vs. control | Rapid vs. intermediate |
|---|---|---|---|
| NEGATIVE IONIZATION | |||
| Phenylalanine | 1.84 ± 0.62 | ||
| Uridine | −2.27 ± 0.88 | 1.62 ± 0.55 | −3.54 ± 1.51 |
| Adenosine | 3.94 ± 2.20 | ||
| 2-Aminomuconic acid semialdehyde | −1.54 ± 0.51 | ||
| 5-Hydroxyindoleacetic acid | 2.26 ± 1.10 | −2.49 ± 1.28 | |
| POSITIVE IONIZATION | |||
| Tryptophan | 2.23 ± 0.94 | 2.48 ± 1.15 | |
The p-values were calculated using ANOVA followed by a Tukey test and the fold changes were calculated using Fieller's theorem for a 95% confidence interval. A positive fold change indicates a higher level in the radiated cells as compared to the control.