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. 2019 Sep 5;12:91. doi: 10.1186/s13045-019-0773-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — LINC01123 promotes tumor growth and aerobic glycolysis in vivo. a A549 cell treated with sh-NC lentivirus were inoculated subcutaneously into the left flanks and treated with sh-1123 lentivirus into the right flanks of nude mice (n = 5). Tumor growth curves showed that sh-1123 group suppressed tumor growth compared with sh-NC group. b ¹⁸F-FDG micro-PET/CT images of living nude mice were conducted 3 weeks after injection. Images showed obvious FDG uptake in sh-NC xenografts, while mild FDG uptake in sh-1123 xenografts. c The xenografts were subjected to H&E and IHC staining with Ki-67 and c-Myc. Scale bar = 50 μm (× 400). Data shown are mean ± SD (n = 3). (*P < 0.05, **P < 0.01, ***P < 0.001)