Fig. 7.

LINC01123 functions as an oncogene via miR-199a-5p and c-Myc. a Colony formation rescue experiment showed that cell proliferation reduced by si-1123 could be increased by miR-199a-5p inhibitor or Myc-OE in H1299 cell. b Colony formation rescue experiment showed that cell proliferation stimulated by ectopic expression of LINC01123 could be repressed by miR-199a-5p mimics or si-Myc in A549 cell. c–e Metabolic functional rescue experiment showed that ¹⁸F-FDG uptake, lactate production, and protein expression level of HK2 and LDHA reduced by si-1123 could be increased by miR-199a-5p inhibitor or Myc-OE in H1299 cell. f–h Metabolic functional rescue experiment showed that ¹⁸F-FDG uptake, lactate production, and protein expression level of HK2 and LDHA promoted by ectopic expression of LINC01123 could be repressed by miR-199a-5p mimics or si-Myc in A549 cell. Scale bar = 100 μm. Data shown are mean ± SD (n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001)