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. 2019 Sep 5;19:887. doi: 10.1186/s12885-019-6110-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Hepatic activation of FOXO3 induces oxidative damage and Akt activation. a Expression of Bcl2l11 (Bim), Sesn2 and Sesn3 by qPCR in livers from 9-week-old control and FOXO3CA^Hep transgenic mice (n = 4). b Representative IHC staining for 8-OHdG (bar = 100 μm) and quantification of 8-OHdG-positive cells as a percentage of total hepatocyte cells in livers of patients in area of small cells (SC) and large cells (LC). c Representative IHC staining for phospho-γH2AX (bar = 100 μm) and quantification of phospho-γH2AX-positive cells as a percentage of total hepatocyte cells in livers of patients in area of small cells and large cells. d Expression of Msh2 by qPCR (upper panel), Western blot analysis for MSH2 (middle panel) and densitometric quantification (lower panel) in livers from 9-week-old control and FOXO3CA^Hep transgenic mice (n = 4). e Western blot analysis in livers from 9-week-old control and FOXO3CA^Hep mice for serine-473 phospho-Akt, with Akt and GAPDH as loading control (left panel), as well as densitometric quantification (right panel). f Representative IHC staining for phospho-Akt in livers from 9-week-old control and FOXO3CA^Hep mice (bar = 100 μm). g Western blot analysis in livers from 9-week-old control and FOXO3CA^Hep mice for Rictor and GAPDH as loading control (left panel), as well as densitometric quantification (right panel)