Table 2.
Association between the FTO-GRS with vitamin B12, folic acid, homocysteine, and obesity traits
| Risk alleles | n | Vitamin B12 (pg/mL) | n | Homocysteine (μmol/L) | n | Folic acid (ng/ml) | n | BMI (kg/m2) | n | WC (cm) | n | Odds Ratio (95% CI) of Obesity |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 380 | 410 ± 202 | 390 | 13.2 ± 7.7 | 390 | 8.89 ± 5.92 | 390 | 26.4 ± 5.0 | 390 | 87.6 ± 11.1 | 194 | 1.63 (1.07-2.49) |
| ≥ 1 | 154 | 356 ± 189 | 157 | 14.8 ± 8.9 | 157 | 7.89 ± 5.48 | 157 | 27.6 ± 5.0 | 156 | 90.0 ± 11.6 | 353 | |
| P value | 0.018 | 0.077 | 0.147 | 0.009† | 0.747 | *0.023 | ||||||
Values are given as mean ± standard deviation
P values for differences between 0 and 1 risk alleles were obtained using linear regression model adjusted age, BMI, type 2 diabetes status, type 2 diabetes medication, and sex
†P values were obtained by using a general linear model adjusted for age, type 2 diabetes status, type 2 diabetes medication, and sex
*P values were adjusted for age, sex, and type 2 diabetes status using binary logistic regression
Abbreviations: BMI body mass index; WC waist circumference; WHR waist to hip ratio