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. 2019 Sep 6;20:351. doi: 10.1186/s12882-019-1534-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Spironolactone (a) suppresses the receptor for advanced glycation end products (RAGEs) expression induced by advanced glycation end products (AGEs) stimulation and (b) increases the phosphorylation of endothelial nitric oxide synthase (p-eNOS) in a dose-dependent manner. * any groups compared with the vehicle group, p < 0.05; # any groups compared with the AGEs group, p < 0.05