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. 2019 Sep 6;20:351. doi: 10.1186/s12882-019-1534-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Application of confocal microscopy to illustrate differences in fluorescence intensity of nicotinamide adenine dinucleotide phosphate oxidase (NOX-2) between different groups. Human aortic endothelial cells (HAECs) treated with the vehicle were used as a negative control group. Compared with the AGEs-stimulated group, pre-treatment with spironolactone (10 μM) in AGEs-stimulated HAECs resulted in a lower fluorescence intensity of NOX-2. Pre-treatment with tenovin-6 (1 μM; the AGEs + spironolactone + tenovin-6 group) resulted in a higher NOX-2 fluorescence intensity than did the AGEs + Spironolactone group