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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Chem Soc Rev. 2018 May 21;47(10):3433–3469. doi: 10.1039/c7cs00818j

Fig. 22.

Fig. 22

A modular approach to presentation of cargo on the exterior of a protein cage. The CP of P22 was genetically engineered to contain a LPETG amino acid sequence at the C-terminal that can be covalently bound to a poly glycine sequence an N-terminal of cargo (here, GFP or hemagglutinin head) via the enzyme sortase. This modular approach allows for many different cargo types to be presented without the need for redesigning the modified CP sequence. Figure reproduced from ref. 288 with permission from the American Chemical Society, copyright 2017.