Skip to main content
. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Chem Soc Rev. 2018 May 21;47(10):3433–3469. doi: 10.1039/c7cs00818j

Fig. 23.

Fig. 23

Overall scheme for the construction of a dually functionalized recombinant bacteriophage MS2. Interior cysteines were modified with porphyrin (purple); exterior p-aminophenylalanine were modified with DNA aptamers (~20 per particle). (A) Live control cells showing the difference in size and shape between Jurkat cells and red blood cells (RBCs). (B) Exposure of the cells to the functionalized MS2 capsids to light for 20 minutes results in selective killing of Jurkat cells as indicated by trypan blue staining. RBCs are left unharmed. (C) Positive control showing death of both cell types induced by 30% ethanol. Scale bars are 100 0μm. Figure adapted from ref. 300 with permission from the American Chemical Society, copyright 2010.