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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Chem Soc Rev. 2018 May 21;47(10):3433–3469. doi: 10.1039/c7cs00818j

Fig. 27.

Fig. 27

Schematic illustration for metal/linker-directed self-assembly of ferritin into three-dimensional crystals. Surface exposed Zn2+ binding sites are engineered at 3-fold symmetry (C3) sites of ferritin by mutating threonine 122 to histidine (T122H). In the presence of ditopic organic linkers, the T122H ferritin mutant forms a BCC lattice through coordination of ferritins at the C3 sites. On the other hand, in the absence of such ditopic linkers, the mutant forms a FCC lattice, which ferritin typically crystalized into, through coordination at 2-fold symmetry (C2) sites. Figure reproduced from ref. 377 with permission from the American Chemical Society, copyright 2015.