Table1.
Ocular disorders
|
Phase | Severity | Dose in mg/min/m 3 (environment air) | Duration | |
---|---|---|---|---|---|
Symptoms | Signs | ||||
Foreign body sensation, tearing, photophobia, blepharospasm, | Eyelids hyperemia, vascular dilation and hyperemia of the conjuctive, | Acute | Mild | 12-70 ( In some cases, more than 100 to 200) |
Up to 2 weeks |
Same as mild damage, dry eye sensation, eye pain | Same as mild damage, conjunctival edema, corneal epithelial edema, corneal epithelial erosion, superficial punctuate keratopathy (more in the lid fissure area) |
Moderate | |||
Same as mild and moderate, severe ocular pain, swelling, redness, sores and spasms of the eyelids, reduced vision | Same as mild and moderate, inflammation, edema and in some cases, secondary infection of the conjunctive, ischemia and necrosis of the conjunctive, limbal ischemia and necrosis, corneal epithelial irregularity and defect, corneal stromal edema, possible corneal infection, inflammation of the anterior chamber (uveitis), perforation of the cornea | Severe | |||
Photophobia, burning, foreign body sensation in eyes, dry eye, tearing, slight redness of the eye | Meibomian gland dysfunction, chronic blepharitis, reduced thickness of the tear meniscus layer, telangiectasia of the conjunctival blood vessels, comma shape vascular tortuosity in the palpebral fissure area (nasal and temporal), subjunctival fibrosis, subconjunctival hemorrage, scarring of the conjunctiva, punctuate epithelia erosions | Chronic and delayed | Mild | 100-200 ( In some cases, more than 200) |
3-6 weeks |
Same as mild damage, reduced vision, marked red eye, itchy eyes, ocular pain | Same as mild damage, corneal irregular astigmatism, periods of relapse and remission, mild to moderate limbal ischemia, irregular cornea, thinning of corneal periphery, corneal opacity as well as lipid and amyloid material and deposition in the corneal periphery, peripheral corneal vascularization, peripheral stromal scars of the cornea, peripheral intra-corneal hemorrhage, transparency of the corneal center, decreased corneal sensation | Moderate | |||
Same as mild and moderate, severe photophobia, severe vision loss, severe pain | Same as mild and moderate, severe limbal ischemia, limbal cell deficiency, thinning and opacity of the central and peripheral parts of the cornea, corneal opacity as well as lipid and amyloid deposition in the cornea, central and peripheral corneal vascularization, band keratopathy and scars in the central and peripheral corneal stroma,central and peripheral intra-corneal hemorrhage, corneal conjunctivalization, corneal descemetocele, corneal ulcer, corneal melting and perforation, history of limbal and corneal surgeries |
Severe | |||
Permanent blindness | > 200 | Very rare |