Figure 1.
Inhibition of mossy fiber fEPSPs by BzATP is reversed by A1 antagonists. A, Time course of fEPSP amplitudes and example traces (average of 5-8 sweeps) from time points indicated by lowercase letters. DPCPX (1 μm) reverses the depression of fEPSPs by BzATP (65 μm); 1 μm DCG-IV was used to confirm the mossy fiber origin of fEPSPs. Horizontal bars represent the drug application time. B, As in A but fEPSPs were recorded in the presence of 1 μm DPCPX. Note that BzATP does not depress fEPSPs under these conditions. C, Summary of the effects of BzATP on mossy fiber fEPSPs in the absence (n = 4) or presence (n = 3) of DPCPX (1 μm).