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. 2004 Jun 2;24(22):5131–5139. doi: 10.1523/JNEUROSCI.1021-04.2004

Figure 5.

Figure 5.

D1 and D2 modulation of AMPA effects on PFC pyramidal cell excitability. Top, Overlays of traces obtained with increasing AMPA concentrations (bottom to top) illustrating the effects of AMPA alone (left), AMPA plus SKF38393 (center), and AMPA plus quinpirole (right). Bottom, Plots summarizing the effects of increasing AMPA concentrations (alone and in the presence of either a D1 or a D2 agonist) on PFC pyramidal cell resting membrane potential, number of evoked spikes, and latency to the first evoked spike. The excitatory effect of AMPA was attenuated in the presence of 0.4 μm quinpirole. SKF38393 failed to change any AMPA-mediated electrophysiological action. *p < 0.03; **p < 0.001; Tukey post hoc test after significant ANOVA.