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. 2004 Jun 23;24(25):5659–5669. doi: 10.1523/JNEUROSCI.1338-04.2004

Figure 8.

Figure 8.

Glial glutamate transporters limit glutamate spillover from excitatory to inhibitory synapses. A, Spontaneous IPSC recorded before (Control) and during repetitive stimulation (Stimulation) of climbing fibers at 10 Hz (40 pulses). B, Average decreases of sIPSC amplitude during climbing fiber stimulation under control conditions and in the presence of d-APV. *p < 0.05. C, Average decreases of sIPSC amplitude induced by stimulation under control conditions (light gray bars) and in the presence of TBOA (dark gray bars) either without or with d-aspartate (d-ASP) in the recording solution. All of these experiments were performed in the presence of the AMPA-kainate receptor antagonist NBQX (20 μm) and in the presence of a type 1 cannabinoid receptor antagonist (1 μm AM-251).