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Letrozole inhibits estrogen synthesis. A dose-dependent decrease in 17β-estradiol release into the medium was found after treatment of slice cultures with various doses of letrozole (▪; mean ± SD; n = 3 cultures per group; ★p < 0.05 to control). Estradiol synthesis was significantly reduced at a dose of 10-7 m letrozole in dispersion cultures (▦; mean ± SD; n = 3 cultures per group; ★p < 0.05 to control).
