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. 2004 Jun 30;24(26):5913–5921. doi: 10.1523/JNEUROSCI.5186-03.2004

Figure 3.


Figure 3.

Letrozole reduces spine density in cultured hippocampal neurons. In hippocampal dispersion cultures, letrozole significantly reduces spine density on apical dendrites of Lucifer yellow-stained and photoconverted pyramidal neurons (n = 16 cells per group; mean ± SD; ★p < 0.01 to control). No significant effect was seen after estradiol treatment.