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. 2004 Jun 30;24(26):5974–5981. doi: 10.1523/JNEUROSCI.0122-04.2004

Figure 2.

Figure 2.

Localization of PrP mRNA in MBP-PrP transgenic mice. In situ hybridization of forebrain sections (A-I) with corpus callosum and of sciatic nerve sections (J-L) of adult Prnp +/+, Prnp o/o, and MBP-PrP transgenic mice is shown. Expression of PrP mRNA occurs in neurons of wild-type (Prnp +/+) forebrains (A) and in Prnp +/+ Schwann cells (J), whereas Prnp o/o brains (B) and nerves (K) lack any signal. In contrast, strong PrP signals are visible in callosal oligodendrocytes (C) and sciatic Schwann cells (I-L) of transgenic mice. D-F, Sense probes did not reveal any signals in brains and sciatic nerves. G-I, The oligodendrocyte-specific PLP antisense probe revealed strong mRNA signals in the forebrains of all genotypes investigated. Scale bars, 50 μm.