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Caspase-3 activation and cytochrome c release in ischemic brain territories after 2 hr of ischemia and 24 hr of reperfusion. a, Activation of caspase-3 after ischemia and its inhibition by creatine pretreatment (whole-brain lysates; each lane represents a separate mouse). cyto. c, Cytochrome c. b, Cytochrome c release after ischemia in mice with or without creatine pretreatment (cytosolic extracts; each lane represents a separate mouse).
