Figure 1.
Effect of RT and FP on [3H]neurotransmitter release from hippocampal synaptosomes. A, Time course and dose dependence of RT-induced inhibition of [3H]NE release. Synaptosomes were exposed to 9 mm [K+]e with or without the indicated concentrations of RT for 3 min (boxed region). B, RT (filled symbols)-induced and FP (open symbols)-induced inhibition of [3H]NE (squares), [3H]GABA (circles), and [3H]d-ASP (diamonds) release evoked by 9 mm [K+]e. Results are expressed as the percentage of inhibition produced by each drug concentration of the integrated AUCs of [3H]neurotransmitter release evoked by 9 mm [K+]e ([3H]NE, 6.85 ± 0.48%; [3H]d-ASP, 2.15 ± 0.15%; [3H]GABA, 3.90 ± 0.27%). Values are means ± SEM of 5-10 separate experiments run in triplicate. *p < 0.05 versus respective control.