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. 2004 Apr 28;24(17):4259–4265. doi: 10.1523/JNEUROSCI.5451-03.2004

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Copyright © 2004 Society for Neuroscience 0270-6474/04/244259-07.00/0

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Figure 7. — Stabilization of AICD by FE65 is LRP independent. Transfected APP-C50-Myc was immunoprecipitated using an anti-MycAb from CHO cell line 13-5-1 deficient in LRP (lanes 1, 2, 5, 6) and LRP expressing CHO-K1 control cell line (lanes 3, 4, 7, 8). APP-C50-Myc was detected using the CT15 anti-APP Ab. Note that cells lacking LRP (13-5-1) show no significant difference in APP-C50-Myc expression neither in the cytoplasmic fraction nor in the nuclear fraction compared with LRP-expressing control CHO-K1 cells.