Figure 3.

Emx-BDNF^KO mice exhibit a foot-clasping phenotype. Emx-BDNF^KO, heterozygous, and wild-type mice of ages 1, 2, and 4 months were suspended by their tails for 1 min. Clasping was defined as the balling up of one or both of the hindlimb paws, accompanied by pulling them into the body and movement of the limbs toward the midline. A, Four-month-old wild-type, heterozygous, and Emx-BDNF^KO mice undergoing tail suspension. B, Rotarod performance of 1-month-old mice (wild type, n = 10; heterozygotes, n = 8; Emx-BDNF^KO, n = 7; ^*p < 0.05 for Emx-BDNF^KO vs wild type). C, Two-month-old mice (wild type, n = 9; heterozygotes, n = 7; Emx-BDNF^KO, n = 10; ^**p < 0.01 for heterozygous vs Emx-BDNF^KO). D, Four-month-old mice (wild type, n = 17; heterozygotes, n = 7; Emx-BDNF^KO, n = 14; ^*p < 0.05 wild type vs Emx-BDNF^KO; ^ζp < 0.01 wild type vs heterozygous; ^***p < 0.001 wild type vs Emx-BDNF^KO). Squares are wild type, triangles are heterozygotes, and circles are Emx-BDNF^KO.