Figure 11.

The overexpression of noggin under the control of the NSE promoter in transgenic mice is associated with significant increases(atp <0.001 in both plexuses) in the number of neurons per square millimeter in the duodenum, jejunum, and ileum. Neuronal perikarya were stained with cuprolinic blue and counted. The quantitative data for the myenteric and submucosal plexuses for wild-type (WT), heterozygous (het), and homozygous (hom) NSE-noggin mice are shown in the graphs at the top of the figure, and representative fields from the proximal ileum of wild-type and homozygous NSE-noggin mice (NSE-Nog) are illustrated in the corresponding panels below the graphs. In myenteric plexus, the increase compared with WT is significantly greater hom > het (at p < 0.001). In submucosal plexus, the increase compared with WT saturates hom = het. Scale bars, 100 μm. ns, Not significant.