Figure 6.

Open-filling cystometry in 5-HT_3A^+/+ and 5-HT_3A^vs/vs mice. Representative cystometrograms from conscious 8-week-old male 5-HT_3A^+/+ (top panel) and 5-HT_3A^vs/vs (bottom panel) mice. Traces illustrate bladder pressure (BP) recorded in response to a constant infusion of saline and accumulated void volumes (VV) recorded with each micturition. Micturition voiding contractions (arrows) were observed in 5-HT_3A^+/+ mice. In contrast, 5-HT_3A^vs/vs mice had a complete loss of micturition contractions, consistent with a phenotype of dribbling overflow incontinence.