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. 2004 May 12;24(19):4657–4667. doi: 10.1523/JNEUROSCI.0797-04.2004

Figure 2.

Figure 2.

RW tau Tg mice develop somato-dendritic NFT-like tau pathology. A-F, Immunostaining using the polyclonal anti-tau antibody 17026 in the spinal cord (A, B), neocortex (C, D), and cerebellum (E, F) of hWT and RW tau Tg mice at 12 months of age. Neurons in RW tau Tg mice progressively accumulated tau in their somato-dendritic compartment, where as neurons in the hWT tau Tg mice showed little or no perikaryal tau immunoreactivity. G, H, High-power photomicrographs demonstrate intense perikaryal tau immunoreactivity in hippocampal hilar neurons of an 18-month-old RW Tg mouse using the 17026 antibody (G), which resemble the filamentous neuronal tau inclusions in the hippocampus of a patient with FTDP-17 caused by a R406W tau gene mutation (H). Some of the tau-positive neurons in the RW tau Tg mice are thioflavin S positive (I), similar to the NFTs in an R406W FTDP-17 brain (J). Scale bars: A-F, 100 μm; G-J, insets, 10 μm.