Skip to main content
. 2004 May 12;24(19):4535–4540. doi: 10.1523/JNEUROSCI.0462-04.2004

Figure 3.

Figure 3.

Increase in synaptic jitter is caused by reduction in input synchrony in ≥14-month-old APP+ cortical neurons. a, b, Individual traces (red) and averages (black) of responses to transcallosal stimuli in 14-month-old nontransgenic (a) and APP (b) neurons injected with QX-314. Dashed lines indicate stimulus. c-f, Responses to transcallosal stimuli in nontransgenic (c, e) and APP (d, f) neurons separated by state. Gray lines indicate individual responses, and heavy black line are averages. c, d, Responses to stimuli in up state; e, f, responses to stimuli in down state. g, h, Average subthreshold amplitudes (g) and probability of state transitions and failures (h) of responses of ≥14-month-old nontransgenic and APP cortical neurons. i, Synaptic jitter is not independent of neuritic curvature. Average curvature and synaptic jitter for 10 measured in 8- to 10-month-old (black; n = 4) and ≥14-month-old (white; n = 6) mice. Error bars denote SD.