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. 2004 Apr 21;24(16):3907–3916. doi: 10.1523/JNEUROSCI.5039-03.2004

Figure 4.

Figure 4.

Dynein complex mutants misaccumulate the anterograde kinesin family motor UNC-104 and native synaptobrevin. a-d, GFP (first image of set) and UNC-104 (second image of set) Ab staining. a, b, dhc-1(js319); jsIs37 SNB-1::GFP misaccumulations (arrow) in the nose also contain the UNC-104 protein. The arrowhead in b points to UNC-104 protein in a SAB neuron. c, d, dli-1(js351); jsIs37 SNB-1::GFP misaccumulations (arrow) in the nose also contain UNC-104 protein. e, f, Dynein heavy chain immunostaining. e, Nerve ring staining in wild type showing that the heavy chain is enriched in neurons. f, Immunoreactivity in unc-104(e1265) animals still shows DHC-1 protein enriched in the nerve ring. g, Double labeling for synaptotagmin (green) and synaptobrevin (red) staining in dhc-1(js319) animals lacking jsIs37 showing a misaccumulation containing both proteins (arrow). Scale bars, 10 μm.