Figure 1.

Anti-CD11d mAb treatment improves open field locomotor scores (BBB) (a) and inclined plane test scores (c) for 12 weeks after SCI at T12 and for 6 weeks after SCI at T4 (b). BBB scores of 1-7 indicate increasing movement of the three hindlimb joints, 8 indicates sweeping of the hind limbs with no weight support, and 10 indicates development of more complex motor control, including consistent weight-supported plantar stepping. The inclined plane test (Rivlin and Tator, 1977) determines the ability of the rat to hold its position on an inclined plane with forelimbs and hindlimbs. □, Control rats (a, c, n = 6); ▪, mAb-treated rats (a, c, n = 9). b, Control 1 and 2 weeks, n = 20; 3-6 weeks, n = 6; mAb 1 and 2 weeks, n = 19; 3-6 weeks, n = 7. Decreased number at 3 weeks in c is caused by autonomic testing and perfusion of rats at 2 weeks after SCI. ^*p < 0.05 compared with control rats.