Figure 2.

β1(-/-) mice show growth retardation and spontaneous seizures. A, Growth retardation in β1 (-/-) mice.β1 (-/-) (left) and β1 (+/+) littermates at P19. The scale is shown in inches. B, Generalized myoclonic seizure in a β1 (-/-) mouse. Electrocorticographic monitoring of P19 β1 (-/-) mice reveals abnormal interictal discharges and seizures during waking behavior. A spontaneous seizure episode of 55 sec duration displayed here shows abrupt bilateral onset and steady acceleration in the frequency of cortical spike discharges, with a sudden return to normal cortical activity at the termination of the seizure. The dotted lines represent 16 sec of continuous seizure activity.