Changes in dopamine neurotransmission after WIN55,212–2 are reversed by SR141716A. Left panel, Spontaneous dopamine transients (asterisk) and dopamine release evoked by electrical stimulation of the MFB (biphasic pulses, 0.4 sec duration, 60 Hz, ±120 μA; black bar). Center panel, Dopamine changes monitored in the 1 min interval after administration of WIN (125 μg/kg). Note that electrically evoked release is reduced by ∼50%. The right trace shows the reversal of these effects by SR (300 μg/kg).