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. 2004 May 19;24(20):4807–4817. doi: 10.1523/JNEUROSCI.5113-03.2004

Figure 4.

Figure 4.

Activation of 5-HT2A receptors depolarizes layer V pyramidal neurons of the rat prefrontal cortex. A1, Application of the selective 5-HT2 receptor agonist DOB induced a depolarization of this layer V pyramidal neuron (P11; Vm, –69 mV). This effect of DOB was blocked by the selective 5-HT2A receptor antagonist MDL 100907 (100 nm). This recording was conducted in the presence of 1 μm TTX. A2, Graph summarizing our pharmacological analysis of the DOB-induced depolarization. The response induced by DOB exhibited a small desensitization determined by two successive applications (8–12 min a part). The depolarizing response to DOB was completely blocked by bath administration of the selective 5-HT2A receptor MDL 100907 (100 nm), whereas the reduction of the DOB-induced depolarization by the selective 5-HT2C antagonist SB 242084 (100 nm) was similar to that expected from desensitization alone. B, Scatter graph showing the peak amplitude of the depolarization induced by application of DOB during the P6–P19 developmental period. Inset, Histogram showing the fraction of neurons that exhibited a depolarizing response to application of DOB across the same developmental window.