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. 2004 May 19;24(20):4758–4766. doi: 10.1523/JNEUROSCI.0594-04.2004

Figure 1.

Figure 1.

Radicicol, an inhibitor of hsp90, diminishes AMPA and NMDA receptor-mediated responses. A, AMPA and NMDA receptor-mediated evoked synaptic responses were recorded in CA1 neurons of the hippocampus during stimulation of the Schaffer collateral pathway. Radicicol (20 μm; Rad) or the equivalent amount of the radicicol vehicle (0.1% DMSO) was added to the perfusion system at the time indicated with an arrow. AMPA and NMDA receptor-mediated currents were recorded in separate experiments, at –60 and +40 mV, respectively. Values are presented as mean ± SEM. Insets, Sample trace of evoked AMPA or NMDA receptor-mediated synaptic responses (as indicated) before (thin line) and 15 min after (thick line) the addition of radicicol or DMSO. Calibration: 20 pA, 20 msec. B, Average series resistance for the recordings shown in A. In addition, we confirmed that radicicol application does not alter membrane input resistance (control, 182 ± 13 MΩ; plus radicicol, 194 ± 15 MΩ).