Figure 7.

Effects of protein synthesis inhibition during 10 probe trials on memory extinction for platform position in the Morris water maze. A, Experimental design. B, First probe trial during 10 trials after 24 hr last training (reexposure; saline, n = 9; ANI, n = 10). Mice were given injections of ANI or saline 30 min before reexposure. C, Extinction curve of time spent swimming in the TQ during 10 probe trials. D, Last probe trial during 10 trials at reexposure. E, Probe trial 24 hr after reexposure (test). B, D, E, Time (seconds) spent in target (T), adjacent left (L), adjacent right (R), and opposite (O) quadrants during the probe trial (60 sec) is shown.