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. 2004 Mar 10;24(10):2527–2534. doi: 10.1523/JNEUROSCI.4315-03.2004

Figure 2.

Figure 2.

Region specificity of apoE fragmentation in NSE-apoE4 mouse brains. Brain tissues from NSE-apoE4 mice (n = 4; age 4-5 months) were dissected into neocortex, hippocampus, and cerebellum and homogenized. ApoE in the homogenates was detected by Western blotting with a polyclonal antibody against full-length apoE. A, Representative Western blot. B, The apoE fragmentation was quantified by measuring the ratio of apoE fragments to full-length apoE. Note that the apoE fragmentation is much more prominent in the neocortex and hippocampus than in the cerebellum (p < 0.001, neocortex or hippocampus vs cerebellum).