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. 2004 Mar 10;24(10):2527–2534. doi: 10.1523/JNEUROSCI.4315-03.2004

Figure 5.

Figure 5.

Age-dependent accumulation of p-tau in brains of NSE-apoE4 mice. p-Tau in brain homogenates of NSE-apoE mice (A, B) and GFAP-apoE mice (C) at different ages was analyzed by Western blotting with monoclonal antibody AT8. Note the higher levels of SDS-resistant p-tau aggregates at the top of the gel in aged NSE-apoE4 mice compared with aged NSE-apoE3 mice. D, Quantitative analysis of the SDS-resistant p-tau aggregates in brain homogenates of NSE-apoE3 and NSE-apoE4 mice (n = 4-6 per genotype and age; p < 0.01, apoE3 vs apoE4 mice at 7-21 months). mE, mouse apoE.