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. 2004 Mar 10;24(10):2412–2420. doi: 10.1523/JNEUROSCI.5544-03.2004

Figure 3.

Figure 3.

Effect of stress or morphine re-exposure on hippocampal synaptic efficacy after chronic morphine. a, Morphine re-exposure (arrow; 3 mg/kg, i.p.) to nonstressed animals failed to induce synaptic potentiation after chronic morphine (2 mg · kg-1 · d-1, s.c.; n = 4; 102.1 ± 0.4% of baseline 90 min after morphine re-exposure; p > 0.05 compared with baseline). b, Morphine re-exposure (arrow; 3 mg/kg, i.p.) also failed to induce synaptic potentiation after a higher dose of chronic morphine (20 mg · kg-1 · d-1, s.c.), and subsequent LFS (3 Hz; bar) failed to induce LTD (n = 5; 100.8 ± 0.6% of baseline 30 min after morphine re-exposure; 101.3 ± 0.6% of baseline 60 min after LFS; p > 0.05 compared with baseline). c, Stress also failed to induce LTD by LFS (3 Hz; bar) after chronic morphine (20 mg · kg-1 · d-1, s.c.; n = 7; 97 ± 0.6% of baseline 60 min after LFS; p > 0.05 compared with baseline).