Figure 9.

Dynamin immunoreactivity in control and HD brain. Immunoperoxidase labeling for dynamin is shown in cortical neurons from control brain (a) and HD brain (b-e). There is a marked redistribution of dynamin in HD grade 1 (b, d, e) and HD grade 3 (c) neurons. Intense immunoreactivity appears in perinuclear regions and on cytoplasmic bodies (d, e, arrows). The staining within nuclei in b and c is cytoplasmic staining within nuclear invaginations. In f, mutant htt labeling detected with EM48 antibody is shown in HD grade 1 cortex. Mutant htt occurs in the nucleus and in cytoplasmic bodies (arrows). In d-f, contrast was enhanced to show cytoplasmic bodies.