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Effect of systemic L-NAME administration on cerebral NOS. A, Calcium-dependent cerebral NOS activity 24 hr after intraperitoneal injections of vehicle or L-NAME at the indicated doses. Data represent the mean ± SD of two experiments; *p < 0.05, compared with mice injected with the vehicle. B, Western blots showing neuronal and endothelial NOS protein in the SVZ, OB, and hippocampus (HPC) of adult mice injected with vehicle (control) or L-NAME (90 mg/kg per day) for 7 d.
