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. 2004 Jan 7;24(1):197–206. doi: 10.1523/JNEUROSCI.4845-03.2004

Figure 2.

Figure 2.

Weak stimulation does not unmask IPSC depression by elevated [K+]o. A, Stimulus I/O curve for a representative IPSC. Stimulus intensity was varied from 70 to 160 μA, whereas the stimulus duration remained constant at 50 μsec. B, IPSCs from the same cell depicted in A. The IPSCs were obtained at a stimulus intensity indicated by the arrow in A. Top, Baseline IPSCs. Bottom, IPSCs in the presence of 10 mm [K+]o. Traces represent the average of eight sweeps in each condition. C, D, Summary results showing the effect on six IPSCs stimulated at less than half maximum stimulus intensity. C, Effect of 10 mm [K+]o on conditioning IPSC amplitude (Norm. 1st IPSC). Conditioning IPSCs in 10 mm [K+]o showed no significant change from control (p = 0.76; n = 6). D, Average effects on IPSC paired-pulse modulation. Note there was a slight decrease in paired-pulse depression of IPSCs, opposite of the effect of elevated [K+]o on EPSCs. *p < 0.05.