Figure 2.

Tone was rated in a subset of newborn pups at rest and during slow- or fast-applied stretch to the forelimb joints and was based on examination proposed by the Task Force on Childhood Motor Disorders (Sanger et al., 2003). Scoring of muscle tone in flexion above the dotted line and that of extension below the dotted line, at rest, or with slow-applied (3 sec) or fast-applied stretch to joint is shown. The dotted line in the ordinate is the zero point with increasing resistance further from the dotted line. Insets show posture of the animals for which the tone data are shown. A, Tone in a normal control pup on flexion and extension. Inset shows the typical posture of a control animal. B-F, Different types of tone abnormalities observed in pups after 40 min sustained hypoxia at E22. Arrows in insets show postural abnormalities.