Figure 6.

Striatal neuron differentiation depends on Gsh2 expression. A-C, H, Cells in Gsh2+/--derived neurospheres express ISL1, at a level indistinguishable from wild-type neurospheres, when differentiated in coculture with primary LGE cells. D-F, H, However, the ability to express ISL1 when differentiated in coculture with primary cells was lost in the Gsh2-/--derived neurospheres. G, The numbers of GFP+ cells with neuronal morphologies were comparable in wild-type, Gsh2+/-, and Gsh2-/- cultures. Error bars indicate SEM. Scale bar, 50 μm.