Figure 6.

GABA_AR activation reduces the speed of neuronal precursor migration by interfering with Ca²⁺ release from intracellular Ca²⁺ stores. A, Average percentage decrease in the speed of neuronal precursor migration induced by 1 mm EGTA, 10 μm BAPTA-AM, or 100 μm 2-APB. ^***p < 0.001. B, Average percentage change in the speed of neuronal precursor migration induced by 10 μm GABA or bicuculline (BIC) in the presence of 100 μm 2-APB. The control speed of migration was measured in the presence of 2-APB. The migration speeds of 90 cells (45 cells in control and 45 cells with a drug) in three slices from juvenile mice were routinely measured per condition. ^*p < 0.05.