Figure 7.

Diagram illustrating the influence of GABA release from neuronal precursors and GABA uptake into astrocyte-like cells on neuronal precursor migration in the SVZ. GABA released from neuronal precursors activates GABA_ARs on surrounding neuronal precursors and reduces the speed of neuronal precursor migration by interacting with Ca²⁺ release from intracellular Ca²⁺ stores. Released GABA is taken up by surrounding astrocyte-like cells that ensheath neuronal precursors and create a microenvironment in which the levels of GABA and the degree of GABA_AR activation are tightly controlled.