Figure 2.

Comparison of significant genes identified by two array platforms. We hypothesized that gene changes important for MPTP pathophysiology would be identified by both Affymetrix and CodeLink arrays. Only genes present on both array platforms were included in the analysis. The overlap was determined by comparing gene information associated with the probe of each platform, using only genes that were significantly differentially expressed (for MME, 425 of 729 genes; for MML, 431 of 763 genes overlapped). Although there were hundreds of gene expression changes that surpassed the significance cutoff, only 11 (A; MME vs MC) or 12 (B; MML vs MC) genes were consistently altered by ALL methods for both array platforms in our study. Of these, four were downregulated at both of the time points examined after MPTP treatment (C).