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. 2004 Aug 25;24(34):7482–7490. doi: 10.1523/JNEUROSCI.1312-04.2004

Figure 3.

Figure 3.

Multiple injections of cocaine potentiate AMPAR/NMDAR ratio lasting for 5 but not 10 d. A, Diagram of injection protocol for single or multiple injections. Rats were treated with single (B) or multiple (C) injections of saline (open bars) or cocaine (filled bars) as previously described. Recordings of AMPAR/NMDAR ratio made 5 d after the final cocaine injection (single injection, n = 9; multiple injections, n = 8) were significantly larger than the saline controls (*p < 0.05; single, n = 6; **p < 0.01; multiple, n = 10). However, AMPAR/NMDAR ratio 10 d after the final cocaine injection (n = 10) was not significantly different from that of the saline controls (n = 10). Bars represent mean AMPAR/NMDAR ratio and SEM.