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. 2004 Jul 7;24(27):6049–6056. doi: 10.1523/JNEUROSCI.0233-04.2004

Figure 1.

Figure 1.

Aβ inhibits induction of NMDAR-dependent LTP, but not induction of NMDAR-independent LTP or LTD, in the rat hippocampus in vitro. A, NMDAR-dependent LTP induced by a single brief HFS in the medial perforant path of the dentate gyrus in control (filled circles) and in the presence of synthetic Aβ (500 nm), applied 40 min before HFS (open circles), reduced significantly from control. B, NMDAR-independent LTP induced by a single brief HFS in CA1 in control (filled circles) and in the presence of synthetic Aβ (1 μm), applied 40 min before HFS (open circles), not reduced significantly from control. C, LTD induced by LFS (1 Hz, 15 min) in the dentate gyrus in control (filled circles) and in the presence of Aβ (500 nm), not reduced significantly from control. The traces above the graphs, labeled a-c in A and a, b in B and C, show field EPSPs at the times indicated. All data shown are the means ± SEM.